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Check Up: Moderna trials mRNA-based HIV vaccine, while these ASX biotechs get patents

In a world first, Cambridge-based Moderna has begun a clinical trial of an experimental vaccine for HIV using its mRNA … Read More
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In a world first, Cambridge-based Moderna has begun a clinical trial of an experimental vaccine for HIV using its mRNA technology.

Best known for its COVID-19 vaccines, Moderna pioneered the use of messenger RNA (or mRNA), a molecule and key ingredient of its Covid jabs.

mRNA itself wasn’t developed in the lab, it evolved billions of years ago and is a naturally found molecule in our bodies that transport DNA cells around the body.

It’s an important safety mechanism as it prevents invaders from hijacking the cellular machinery to produce foreign protein, hence its effective use as an ingredient in vaccines.

The Moderna HIV trial has now commenced, administering first doses to participants at the George Washington University.

The company says the goal is to draw out an immune response from the body when presented with HIV-specific antigens delivered through the vaccine.

Meanwhile, biotech stocks in the US have had a bleak start to the year, with SPDR S&P Biotech ETF, a key benchmark for the sector, down by 18% so far in 2022.

The ETF is one of the funds targeted heavily by short sellers as a Fed rate hike looms around the corner.

Down Under, investor mood is similar with ASX 200 Health Index (XHJ) already down by 12% in the first month of trading this year.

As elsewhere globally, risk-off sentiment has weighed on local stocks after a shock 3.5% inflation print last week.

However, some good quality healthcare names have caught a bid over the last few days.

CODE COMPANY PRICE 1 WEEK RETURN % 6 MONTH RETURN % 1 YEAR RETURN % MARKET CAP
RAP Resapp Health Ltd 0.08 37.9% 23.1% 21.2% $63,580,584
IDT IDT Australia Ltd 0.255 30.8% 0.0% 27.5% $67,160,848
NOX Noxopharm Limited 0.445 27.1% 14.1% -39.0% $131,507,078
NEU Neuren Pharmaceut. 3.91 23.7% 3.7% 185.4% $496,304,763
NXS Next Science Limited 1.245 23.3% 0.0% 3.8% $253,406,604
NC6 Nanollose Limited 0.11 22.2% 10.0% -15.4% $17,121,932
AVE Avecho Biotech Ltd 0.017 21.4% 13.3% -15.0% $23,891,563
AMT Allegra Orthopaedics 0.15 20.0% 0.0% -50.8% $15,668,880
IPD Impedimed Limited 0.19 18.8% 8.6% 65.2% $337,610,167
VHT Volpara Health Tech 0.95 17.3% -8.7% -36.0% $241,402,638
PAB Patrys Limited 0.028 16.7% -24.3% 4.1% $59,644,953
IMC Immuron Limited 0.14 16.7% 40.0% -34.9% $30,752,777
M7T Mach7 Tech Limited 0.7925 16.5% -3.4% -46.8% $183,534,157
CBL Control Bionics 0.44 15.8% 3.5% -45.7% $21,642,290
SHG Singular Health 0.265 15.2% -5.4% 0.0% $17,301,603
IMU Imugene Limited 0.3275 14.9% -18.1% 227.5% $1,915,882,925
VBS Vectus Biosystems 1.395 14.3% -1.1% 4.9% $45,403,691
MEM Memphasys Ltd 0.074 13.8% -20.4% -23.7% $57,829,019
ALC Alcidion Group Ltd 0.255 13.3% -7.3% 23.8% $323,357,609
ATH Alterity Therap Ltd 0.0215 13.2% 2.4% -38.6% $50,544,366
MEB Medibio Limited 0.0045 12.5% -10.0% -43.8% $8,244,204
GTG Genetic Technologies 0.0045 12.5% -10.0% -55.0% $41,552,843
AT1 Atomo Diagnostics 0.225 12.5% -25.0% -21.1% $91,955,326
KZA Kazia Therapeutics 1.01 12.2% -19.5% -17.6% $126,755,721
TRP Tissue Repair 0.46 12.2% -15.6% 0.0% $19,784,561
IMM Immutep Ltd 0.425 11.8% -13.3% 7.6% $345,919,734
MVP Medical Developments 4.62 11.3% -7.6% -30.3% $329,313,863
PNV Polynovo Limited 1.4 11.1% -8.2% -47.6% $893,278,859
TLX Telix Pharmaceutical 7.34 10.9% -5.3% 89.2% $2,178,088,807
LDX Lumos Diagnostics 1.05 10.5% 5.5% 0.0% $140,762,626
PGC Paragon Care Limited 0.37 10.4% 2.8% 57.4% $126,504,252
RHY Rhythm Biosciences 1.375 10.4% -11.3% 14.9% $300,176,771
NSB Neuroscientific 0.32 10.3% -4.5% 48.8% $43,041,493
PIQ Proteomics Int Lab 1.05 9.9% -13.6% 54.4% $114,108,345
AGH Althea Group 0.225 9.8% 0.0% -50.0% $69,248,863
ATX Amplia Therapeutics 0.17 9.7% 3.0% -33.9% $32,955,180
TD1 Tali Digital Limited 0.0175 9.4% -20.5% -55.1% $15,842,398
1AD Adalta Limited 0.082 9.3% 2.5% -31.0% $24,652,229
OCC Orthocell Limited 0.435 8.8% -14.7% -10.3% $87,721,921
PYC PYC Therapeutics 0.125 8.7% -7.4% -7.4% $413,520,393
ACW Actinogen Medical 0.125 8.7% -21.9% 525.0% $231,250,057
OSX Osteopore Limited 0.25 8.7% 11.1% -50.0% $27,558,036
DXB Dimerix Ltd 0.255 8.5% 4.1% -15.0% $83,427,153
PTX Prescient Ltd 0.205 7.9% -10.9% 95.2% $136,519,573
IBX Imagion Biosys Ltd 0.07 7.7% -7.9% -57.6% $76,242,860
ALA Arovella Therapeutic 0.043 7.5% 10.3% -4.4% $25,248,346
RAC Race Oncology Ltd 3.07 7.3% -14.7% 78.5% $486,306,585
BDX Bcaldiagnostics 0.105 7.1% -16.0% 0.0% $15,130,787
HCT Holista CollTech Ltd 0.045 7.1% -4.3% -30.8% $12,941,407
PAA Pharmaust Limited 0.105 7.1% 5.0% 7.1% $31,374,326
IIQ Inoviq Ltd 1.095 6.8% -8.4% 88.8% $97,539,824
MX1 Micro-X Limited 0.235 6.8% -7.8% -32.9% $108,133,124
GLH Global Health Ltd 0.395 6.8% 12.9% -12.2% $22,360,710
TSN The Sust Nutri Grp 0.16 6.7% -20.0% -62.8% $19,297,022
RAD Radiopharm 0.325 6.6% -17.7% 0.0% $41,507,606
RAD Radiopharm 0.325 6.6% -17.7% 0.0% $41,507,606
CGS Cogstate Ltd 1.825 6.4% -24.6% 58.0% $312,002,996
PAR Paradigm Bio. 1.47 5.8% -22.0% -37.4% $341,393,693
IHL Incannex Healthcare 0.465 5.7% -25.6% 200.0% $549,880,241
IVX Invion Ltd 0.019 5.6% -9.5% 90.0% $121,913,759
MDR Medadvisor Limited 0.38 5.6% -3.8% 4.1% $141,703,448
MVF Monash IVF Group Ltd 1.035 5.1% -1.9% 38.0% $393,531,188
SOM SomnoMed Limited 2.11 5.0% -10.2% 9.9% $174,622,155
PXS Pharmaxis Ltd 0.1 4.2% -16.7% 9.9% $54,892,316
ONE Oneview Healthcare 0.25 4.2% -5.7% 168.8% $126,627,210
ILA Island Pharma 0.25 4.2% -2.0% 0.0% $10,810,792
OVN Oventus Medical Ltd 0.075 4.2% -13.8% -63.4% $18,129,490
AHC Austco Healthcare 0.13 4.0% -10.3% 18.2% $36,944,564
CPH Creso Pharma Ltd 0.085 3.7% 3.7% -60.5% $103,172,247
CU6 Clarity Pharma 0.72 3.6% -2.7% 0.0% $130,348,264
CAN Cann Group Ltd 0.29 3.6% -1.7% -52.5% $97,754,587
ZLD Zelira Therapeutics 0.029 3.6% -12.1% -63.3% $37,155,718
BOT Botanix Pharma Ltd 0.062 3.3% 10.7% -57.2% $56,442,240
PSQ Pacific Smiles Grp 2.69 3.1% -8.2% 3.5% $416,508,858
EPN Epsilon Healthcare 0.069 3.0% -2.8% -70.6% $14,698,659
ARX Aroa Biosurgery 0.865 3.0% -15.2% -19.9% $287,528,752
CYC Cyclopharm Limited 1.79 2.9% 9.1% -34.9% $164,806,563
CAJ Capitol Health 0.37 2.8% -5.1% 37.0% $390,831,567
EXL Elixinol Wellness 0.074 2.8% 2.8% -58.9% $22,113,782
GSS Genetic Signatures 1.325 2.7% -26.0% -29.5% $197,493,519
RCE Recce Pharmaceutical 1.2 2.6% 16.5% 18.8% $213,759,052
NYR Nyrada Inc. 0.205 2.5% -14.6% -48.8% $33,541,871
OSL Oncosil Medical 0.041 2.5% -8.9% -67.2% $30,109,045
DOC Doctor Care Anywhere 0.49 2.1% -22.8% -61.6% $96,054,251
RSH Respiri Limited 0.051 2.0% -20.3% -57.5% $36,864,880
EYE Nova EYE Medical Ltd 0.295 1.7% -9.2% -10.6% $42,938,368
HXL Hexima 0.38 1.3% -8.4% 130.3% $60,156,722
TRU Truscreen 0.076 1.3% 1.3% -41.5% $25,400,638
CYP Cynata Therapeutics 0.48 1.1% -11.9% -26.7% $66,623,616
VLS Vita Life Sciences.. 1.955 0.8% 2.9% 99.5% $99,513,437
PBP Probiotec Limited 2.28 0.4% 3.6% 0.4% $186,230,600
UBI Universal Biosensors 0.8575 0.3% -13.4% 86.4% $152,932,513
ALT Analytica Limited 0.002 0.0% 0.0% -42.9% $9,227,602
ADR Adherium Ltd 0.013 0.0% 18.2% -43.5% $28,610,351
ACR Acrux Limited 0.096 0.0% -4.0% -48.1% $27,233,312
SCU Stemcell United Ltd 0.014 0.0% 0.0% -12.5% $14,606,489
ICS ICSGlobal Limited 0.575313 0.0% 0.0% 11.7% $6,054,605
FFC Farmaforce Ltd 0.054 0.0% 17.4% -40.0% $7,056,773
CHM Chimeric Therapeutic 0.22 0.0% -15.4% -31.3% $50,686,782
MDC Medlab Clinical Ltd 0.125 0.0% -16.7% -59.7% $46,193,716
BPH BPH Energy Ltd 0.037 0.0% 0.0% -78.2% $24,602,017
PAL Palla Pharma Ltd 0.295 0.0% 0.0% -52.3% $47,764,383
LCT Living Cell Tech. 0.005 0.0% -16.7% -65.1% $5,141,819
BNO Bionomics Limited 0.095 -1.0% -13.6% -31.5% $124,508,268
NTI Neurotech Intl 0.05 -2.0% -16.7% 8.7% $33,489,558
EZZ EZZ Life Science 0.45 -2.2% -11.8% 0.0% $5,742,000
CMP Compumedics Limited 0.38 -2.6% 2.7% -17.4% $65,550,291
BIT Biotron Limited 0.071 -2.7% -26.8% -1.4% $48,433,357
ANP Antisense Therapeut. 0.17 -2.9% -12.8% -2.9% $117,038,946
SDI SDI Limited 0.925 -3.1% -8.9% 20.1% $109,950,615
RGS Regeneus Ltd 0.083 -3.5% 3.8% -27.8% $24,821,390
BWX BWX Limited 3.41 -3.7% -21.6% -15.2% $547,118,548
CTE Cryosite Limited 0.43 -4.4% -7.5% -3.4% $20,988,112
IRX Inhalerx Limited 0.084 -4.5% -6.7% -30.0% $14,151,224
AHK Ark Mines Limited 0.2 -4.8% -14.9% 488.2% $6,212,021
DVL Dorsavi Ltd 0.019 -5.0% -5.0% -47.2% $6,723,744
OPT Opthea Limited 1.15 -5.3% -11.2% -40.1% $404,730,172
AN1 Anagenics Limited 0.05 -5.7% -16.7% -46.3% $11,272,086
LBT LBT Innovations 0.094 -6.0% -18.3% -6.0% $29,750,844
RHT Resonance Health 0.15 -6.3% 7.1% -18.9% $71,432,057
OSP Osprey Med Inc 0.4575 -6.6% -26.2% -77.1% $11,674,637
RNO Rhinomed Ltd 0.2725 -6.8% -12.1% 137.0% $71,447,511
PCK Painchek Ltd 0.0475 -6.9% -10.4% -30.1% $54,326,630
OIL Optiscan Imaging 0.135 -6.9% -25.0% 22.7% $92,877,840
1ST 1St Group Ltd 0.013 -7.1% -7.1% -56.9% $7,052,863
ICR Intelicare Holdings 0.083 -7.8% -8.8% -63.7% $7,515,083
S66 Star Combo 0.295 -7.8% 15.7% -1.7% $39,678,379
HGV Hygrovest Limited 0.046 -8.0% -22.0% -60.0% $10,577,883
4DX 4Dmedical Limited 1.02 -8.9% -24.4% -53.6% $214,179,657
JTL Jayex Technology Ltd 0.019 -9.5% 0.0% -52.5% $4,984,571
AC8 Auscann Grp Hlgs Ltd 0.072 -10.0% -11.1% -60.0% $31,278,845
MXC Mgc Pharmaceuticals 0.033 -10.8% -10.8% 26.9% $83,655,639
CDX Cardiex Limited 0.046 -11.5% -33.3% -45.2% $50,578,505
VTI Vision Tech Inc 0.805 -14.8% -8.0% -55.3% $20,090,175
BXN Bioxyne Ltd 0.02 -20.0% -31.0% 81.8% $12,802,908
ZNO Zoono Group Ltd 0.29 -20.5% -22.7% -72.1% $47,427,336
ADO Anteotech Ltd 0.215 -34.8% -29.5% 115.0% $444,224,756
ONT 1300 Smiles Limited 0 -100.0% -100.0% -100.0% $168,827,115

 

Avecho enters the US recreational cannabis market

After securing a deal in December with Medterra Pharma for its arthritis CBD soft-gel capsule, Avecho Biotech (ASX:AVE) surged by 23% on Wednesday following another deal in the US.

Avecho announced a licensing agreement with Team SAAS on the use of TPM (tocopheryl phosphate mixture) for the US recreational cannabis market.

Under the terms, Avecho grants SAAS exclusive rights to commercialise a recreational cannabis distillate containing TPM for use in the manufacture of edible cannabis products in the US. 

This deal signals a strategic step forward in Avecho’s ambitions to increase the breadth of cannabis products that leverages its TPM formulations.

The company said the deal occured in parallel to its existing work to register its CBD soft-gel product for sleep indications with the TGA in Australia.

Avecho share price today:



 

International patent grants for two ASX biotechs

Dimerix (ASX:DXB)

The company confirmed another key milestone this week with news that the Danish Medicines Agency has issued regulatory approval for the ACTION3 Phase 3 study in Denmark.

Dimerix’s pivotal Phase III clinical trial, ACTION3, will evaluate the efficacy and safety of DMX-200 against a placebo in patients with Focal Segmental Glomerulosclerosis (FSGS) kidney disease.

This year is shaping up as a busy year for Dimerix as it executes on a multi-channel development approach for its proprietary DMX-200 drug treatment.

ResApp Health (ASX:RAP)

Brisbane-based ResApp has announced that the China National Intellectual Property Administration has accepted for grant its patent application titled “A method and apparatus for processing patient sounds”.

The patent is owned by the University of Queensland, and is licensed to ResApp for the lifetime of the patent.

The patent family has also been granted in Australia, Japan, Korea, the US and is pending in Australia.

ResApp develops smartphone applications for diagnosis and management of respiratory disease.

 

 


 

Two biotechs notching gains after announcements

IDT Australia (ASX:IDT)

IDT rose strongly in the past week despite the expiry of the Sterile Readiness Agreement signed with Australian Government Department of Health.

In August, IDT agreed to ensure the production capacity of its sterile facility would be retained exclusively for the Health department.

The company said that after the lapse of the contract, it remains in active discussions with the government on several fronts regarding mRNA product translation/manufacturing.

Next Science (ASX:NXS)

Next Science and Zimmer Inc have executed a distribution agreement for Zimmer to sell a white labelled version of XPERIENCE into the US market under Zimmer’s own labelling.

The agreement is effective immediately and has a five-year term plus a five-year renewal option

Next Science says its revenues received from sales of the Zimmer white label XPERIENCE product to become material.

XPERIENCE is a no-rinse solution that’s designed to help prevent surgical site and post-operative infections by rinsing away debris and microorganisms.

 


 

At Stockhead we tell it like it is. While Dimerix is a Stockhead advertiser, it did not sponsor this article.

The post Check Up: Moderna trials mRNA-based HIV vaccine, while these ASX biotechs get patents appeared first on Stockhead.

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